Adenosine is a ubiquitous extracellular signaling molecule with essential functions in human
physiology. Due to the widespread expression of adenosine receptors, it has far-reaching …

Objectives: The goal of this study was to identify clinical and lesion-specific local factors
affecting visual-functional mismatch. Background: Although lesion severity determined by …

Physiological assessment of coronary artery disease (CAD) has become one of the
cornerstones of decision making for myocardial revascularization, with a large body of …

Background—Significant left main coronary artery stenosis is an accepted indication for
surgical revascularization. The potential of angiography to evaluate the hemodynamic …

Background—Fractional flow reserve derived from computed tomography angiography
(FFRCT) is a noninvasive method for diagnosis of ischemic coronary lesions. To date, the …

Background—Computed tomography (CT) is increasingly used to detect coronary artery
disease, but the evaluation of stenoses is often uncertain. Perfusion imaging has an …

Pressure wire–based fractional flow reserve is considered the standard of reference for
evaluation of the ischemic potential of coronary stenoses and the expected benefit from …

Objectives: This study sought to determine if adenosine administration is required for the
pressure-only assessment of coronary stenoses. Background: The instantaneous wave-free …

Background Coronary arteries without focal stenosis at angiography are generally
considered non–flow-limiting. However, atherosclerosis is a diffuse process that often …

A Report of the American College of Cardiology Foundation/American Heart Association
Task Force on Practice Guidelines