Microglia represent the first line of immune feedback in the brain. Beyond immune
surveillance, they are essential for maintaining brain homeostasis. Recent research has …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder that manifests as motor
and nonmotor symptoms due to the selective loss of midbrain DArgic (DA) neurons. More …

Chronic neuroinflammation has been considered to be involved in the progressive
dopaminergic neurodegeneration in Parkinson's disease (PD). However, the mechanisms …

Rotenone is a neurotoxic pesticide widely used in agriculture. Dopaminergic neuron has
long been considered as the target of rotenone. We recently reported that rotenone …

Aim The complement cascade is activated and may play an important pathophysiologic role
in brain injury after experimental intracerebral hemorrhage (ICH). However, the exact …

Objectives Parkinson's disease (PD) is a common neurodegenerative disorder
characterized by the progressive and selective degeneration of dopaminergic neurons …

Current treatment of Parkinson's disease (PD) ameliorates symptoms but fails to block
disease progression. This study was conducted to explore the protective effects of SVHRSP …

Reactive microglia are observed with aging and in Lewy body disorders, including within the
olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia …

Rotenone is a commercial pesticide commonly used to model Parkinson's disease (PD) due
to its ability to induce dopaminergic degeneration. Studies have confirmed that rotenone …

Microglia-mediated chronic neuroinflammation has been associated with cognitive decline
induced by rotenone, a well-known neurotoxic pesticide used in agriculture. However, the …