Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases
N Javanmehr, K Saleki, P Alijanizadeh… - Journal of …, 2022 - Springer
Microglia represent the first line of immune feedback in the brain. Beyond immune
surveillance, they are essential for maintaining brain homeostasis. Recent research has …
surveillance, they are essential for maintaining brain homeostasis. Recent research has …
Mechanisms of autoimmune cell in DA neuron apoptosis of Parkinson's disease: recent advancement
Z Zheng, S Zhang, H Zhang, Z Gao… - Oxidative Medicine …, 2022 - Wiley Online Library
Parkinson's disease (PD) is a prevalent neurodegenerative disorder that manifests as motor
and nonmotor symptoms due to the selective loss of midbrain DArgic (DA) neurons. More …
and nonmotor symptoms due to the selective loss of midbrain DArgic (DA) neurons. More …
Microglial activation damages dopaminergic neurons through MMP-2/-9-mediated increase of blood-brain barrier permeability in a Parkinson's disease mouse model
Chronic neuroinflammation has been considered to be involved in the progressive
dopaminergic neurodegeneration in Parkinson's disease (PD). However, the mechanisms …
dopaminergic neurodegeneration in Parkinson's disease (PD). However, the mechanisms …
Rotenone impairs learning and memory in mice through microglia-mediated blood brain barrier disruption and neuronal apoptosis
Z Guo, Z Ruan, D Zhang, X Liu, L Hou, Q Wang - Chemosphere, 2022 - Elsevier
Rotenone is a neurotoxic pesticide widely used in agriculture. Dopaminergic neuron has
long been considered as the target of rotenone. We recently reported that rotenone …
long been considered as the target of rotenone. We recently reported that rotenone …
Role of complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment
Y Zheng, L Fan, S Xia, Q Yang, Z Zhang… - Frontiers in …, 2022 - frontiersin.org
Aim The complement cascade is activated and may play an important pathophysiologic role
in brain injury after experimental intracerebral hemorrhage (ICH). However, the exact …
in brain injury after experimental intracerebral hemorrhage (ICH). However, the exact …
Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson's disease
Objectives Parkinson's disease (PD) is a common neurodegenerative disorder
characterized by the progressive and selective degeneration of dopaminergic neurons …
characterized by the progressive and selective degeneration of dopaminergic neurons …
A novel synthetic peptide SVHRSP attenuates dopaminergic neurodegeneration by inhibiting NADPH oxidase-mediated neuroinflammation in experimental models of …
X Zhang, D Tu, S Li, N Li, D Li, Y Gao, L Tian… - Free Radical Biology …, 2022 - Elsevier
Current treatment of Parkinson's disease (PD) ameliorates symptoms but fails to block
disease progression. This study was conducted to explore the protective effects of SVHRSP …
disease progression. This study was conducted to explore the protective effects of SVHRSP …
[HTML][HTML] A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes
TN Bhatia, AS Jamenis, M Abbas, RN Clark… - Neurobiology of …, 2023 - Elsevier
Reactive microglia are observed with aging and in Lewy body disorders, including within the
olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia …
olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia …
PACAP and VIP mitigate rotenone-induced inflammation in BV-2 microglial cells
Rotenone is a commercial pesticide commonly used to model Parkinson's disease (PD) due
to its ability to induce dopaminergic degeneration. Studies have confirmed that rotenone …
to its ability to induce dopaminergic degeneration. Studies have confirmed that rotenone …
[HTML][HTML] Complement receptor 3-mediated neurotoxic glial activation contributes to rotenone-induced cognitive decline in mice
Q Wang, Z Ruan, L Jing, Z Guo, X Zhang, J Liu… - Ecotoxicology and …, 2023 - Elsevier
Microglia-mediated chronic neuroinflammation has been associated with cognitive decline
induced by rotenone, a well-known neurotoxic pesticide used in agriculture. However, the …
induced by rotenone, a well-known neurotoxic pesticide used in agriculture. However, the …