Antiphospholipid syndrome
K Schreiber, S Sciascia, PG De Groot… - Nature reviews Disease …, 2018 - nature.com
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence
of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and …
of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and …
Pathogenesis of antiphospholipid syndrome: understanding the antibodies
PL Meroni, MO Borghi, E Raschi… - Nature Reviews …, 2011 - nature.com
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …
Antiphospholipid syndrome: role of vascular endothelial cells and implications for risk stratification and targeted therapeutics
MT Corban, A Duarte-Garcia, RD McBane… - Journal of the American …, 2017 - jacc.org
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous
thromboembolism, arterial thrombosis, and obstetric morbidities in the setting of persistently …
thromboembolism, arterial thrombosis, and obstetric morbidities in the setting of persistently …
β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome
Ç Ağar, GMA van Os, M Mörgelin… - Blood, The Journal …, 2010 - ashpublications.org
The antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies in
blood of patients with thrombosis or fetal loss. There is ample evidence that β2-glycoprotein I …
blood of patients with thrombosis or fetal loss. There is ample evidence that β2-glycoprotein I …
Thrombus formation induced by antibodies to β2-glycoprotein I is complement dependent and requires a priming factor
F Fischetti, P Durigutto, V Pellis, A Debeus, P Macor… - Blood, 2005 - ashpublications.org
We monitored the number of intravascular platelet-leukocyte aggregates (PLAs) and
thrombotic occlusions (TOs) by intravascular microscopy in the mesentery of rats receiving …
thrombotic occlusions (TOs) by intravascular microscopy in the mesentery of rats receiving …
Requirement of activation of complement C3 and C5 for antiphospholipid antibody–mediated thrombophilia
SS Pierangeli, G Girardi, M Vega‐Ostertag… - Arthritis & …, 2005 - Wiley Online Library
Objective Antiphospholipid antibodies (aPL) have been shown to induce thrombosis,
activate endothelial cells, and induce fetal loss. The pathogenesis of aPL‐induced …
activate endothelial cells, and induce fetal loss. The pathogenesis of aPL‐induced …
[HTML][HTML] β2‐Glycoprotein I: evolution, structure and function
PG De Groot, JCM Meijers - Journal of Thrombosis and Haemostasis, 2011 - Elsevier
Summary β 2‐Glycoprotein I (β 2‐GPI) is a protein that circulates in blood at high
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …
Microvascular thrombosis: experimental and clinical implications
MA Bray, SE Sartain, J Gollamudi, RE Rumbaut - Translational Research, 2020 - Elsevier
A significant amount of clinical and research interest in thrombosis is focused on large
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …
Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms
SS Pierangeli, PP Chen, E Raschi… - … in thrombosis and …, 2008 - thieme-connect.com
Antiphospholipid antibodies (Abs) are associated with thrombosis and are a risk factor for
recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid …
recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid …
Current concepts on the pathogenesis of the antiphospholipid syndrome
The antiphospholipid syndrome (APS) is an important cause of acquired thrombophilia. It is
characterized by the core clinical manifestations of thrombosis, either venous or arterial, and …
characterized by the core clinical manifestations of thrombosis, either venous or arterial, and …