Antiphospholipid syndrome

K Schreiber, S Sciascia, PG De Groot… - Nature reviews Disease …, 2018 - nature.com
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence
of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and …

Pathogenesis of antiphospholipid syndrome: understanding the antibodies

PL Meroni, MO Borghi, E Raschi… - Nature Reviews …, 2011 - nature.com
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …

Antiphospholipid syndrome: role of vascular endothelial cells and implications for risk stratification and targeted therapeutics

MT Corban, A Duarte-Garcia, RD McBane… - Journal of the American …, 2017 - jacc.org
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous
thromboembolism, arterial thrombosis, and obstetric morbidities in the setting of persistently …

β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome

Ç Ağar, GMA van Os, M Mörgelin… - Blood, The Journal …, 2010 - ashpublications.org
The antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies in
blood of patients with thrombosis or fetal loss. There is ample evidence that β2-glycoprotein I …

Thrombus formation induced by antibodies to β2-glycoprotein I is complement dependent and requires a priming factor

F Fischetti, P Durigutto, V Pellis, A Debeus, P Macor… - Blood, 2005 - ashpublications.org
We monitored the number of intravascular platelet-leukocyte aggregates (PLAs) and
thrombotic occlusions (TOs) by intravascular microscopy in the mesentery of rats receiving …

Requirement of activation of complement C3 and C5 for antiphospholipid antibody–mediated thrombophilia

SS Pierangeli, G Girardi, M Vega‐Ostertag… - Arthritis & …, 2005 - Wiley Online Library
Objective Antiphospholipid antibodies (aPL) have been shown to induce thrombosis,
activate endothelial cells, and induce fetal loss. The pathogenesis of aPL‐induced …

[HTML][HTML] β2‐Glycoprotein I: evolution, structure and function

PG De Groot, JCM Meijers - Journal of Thrombosis and Haemostasis, 2011 - Elsevier
Summary β 2‐Glycoprotein I (β 2‐GPI) is a protein that circulates in blood at high
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …

Microvascular thrombosis: experimental and clinical implications

MA Bray, SE Sartain, J Gollamudi, RE Rumbaut - Translational Research, 2020 - Elsevier
A significant amount of clinical and research interest in thrombosis is focused on large
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …

Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms

SS Pierangeli, PP Chen, E Raschi… - … in thrombosis and …, 2008 - thieme-connect.com
Antiphospholipid antibodies (Abs) are associated with thrombosis and are a risk factor for
recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid …

Current concepts on the pathogenesis of the antiphospholipid syndrome

B Giannakopoulos, F Passam, S Rahgozar, SA Krilis - Blood, 2007 - ashpublications.org
The antiphospholipid syndrome (APS) is an important cause of acquired thrombophilia. It is
characterized by the core clinical manifestations of thrombosis, either venous or arterial, and …