A comprehensive review on the role of the gut microbiome in human neurological disorders

SG Sorboni, HS Moghaddam… - Clinical microbiology …, 2022 - Am Soc Microbiol
The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

The microbiota-gut-brain axis: from motility to mood

KG Margolis, JF Cryan, EA Mayer - Gastroenterology, 2021 - Elsevier
The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and
extrinsic factors influence signaling along this axis, modulating the function of both the …

[HTML][HTML] The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

A Rutsch, JB Kantsjö, F Ronchi - Frontiers in immunology, 2020 - frontiersin.org
The human microbiota has a fundamental role in host physiology and pathology. Gut
microbial alteration, also known as dysbiosis, is a condition associated not only with …

[HTML][HTML] Nutritional components in Western diet versus Mediterranean diet at the gut microbiota–immune system interplay. Implications for health and disease

C García-Montero, O Fraile-Martínez… - Nutrients, 2021 - mdpi.com
The most prevalent diseases of our time, non-communicable diseases (NCDs)(including
obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising …

[HTML][HTML] The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Microbiota-derived metabolites as drivers of gut–brain communication

H Ahmed, Q Leyrolle, V Koistinen, O Kärkkäinen… - Gut …, 2022 - Taylor & Francis
Alterations in the gut microbiota composition have been associated with a range of
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …

[HTML][HTML] Tryptophan metabolism and gut-brain homeostasis

W Roth, K Zadeh, R Vekariya, Y Ge… - International journal of …, 2021 - mdpi.com
Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

Y Li, Y Peng, Y Shen, Y Zhang, L Liu… - Critical Reviews in Food …, 2023 - Taylor & Francis
Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation,
rearrangement and cross-linking between the active carbonyl groups of reducing sugars …

[HTML][HTML] Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders

J Horn, DE Mayer, S Chen, EA Mayer - Translational psychiatry, 2022 - nature.com
There is emerging evidence that diet has a major modulatory influence on brain-gut-
microbiome (BGM) interactions with important implications for brain health, and for several …

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

M Platten, EAA Nollen, UF Röhrig, F Fallarino… - Nature reviews Drug …, 2019 - nature.com
Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …