Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Transition metals are required trace elements for all forms of life. Due to their unique
inorganic and redox properties, transition metals serve as cofactors for enzymes and other …

Autophagy, a cellular homeostatic process, which ensures cellular survival under various
stress conditions, has catapulted to the forefront of innate defense mechanisms during …

Indoleamine 2, 3‐dioxygenase 1 (IDO1) catalyzes the initial rate‐limiting step in the
degradation of the essential amino acid tryptophan along the kynurenine pathway. When …

Bacteria that cause disease rely on their ability to counteract and overcome host defenses.
Here, we present a genome-scale study of Mycobacterium tuberculosis (Mtb) that uncovers …

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to
support growth in macrophages. By conducting an extensive, unbiased chemical screen to …

Plant-pathogenic Ralstonia spp. colonize plant xylem and cause wilt diseases on a broad
range of host plants. To identify genes that promote growth of diverse Ralstonia strains in …

Significance: Proline metabolism has complex roles in a variety of biological processes,
including cell signaling, stress protection, and energy production. Proline also contributes to …

Salmonella strains are traditionally classified into serovars based on their surface antigens.
While increasing availability of whole-genome sequences has allowed for more detailed …

Bacterial pathogenicity relies on a proficient metabolism and there is increasing evidence
that metabolic adaptation to exploit host resources is a key property of infectious organisms …