Current scenario of fused pyrimidines with in vivo anticancer therapeutic potential

Z Xu, L Wang, H Hu - Archiv der Pharmazie, 2024 - Wiley Online Library
Cancer, characterized by uncontrolled cell growth and metastasis, is responsible for nearly
one in six deaths and represents a severe threat to public health worldwide. Chemotherapy …

Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based …

T Yu, R Zeng, Y Guan, B Pan, HW Li, J Gu… - RSC Medicinal …, 2024 - pubs.rsc.org
The discovery of novel and highly effective P-gp inhibitors is considered to be an effective
strategy for overcoming tumor drug resistance. In this paper, a phenotypic screening via a …