Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

Prevention of atherosclerosis is important because it is a risk factor for cardiovascular
diseases globally. One of the causes of atherosclerosis is accumulation of cholesterol and …

Proper coordination of cholesterol biosynthesis and trafficking is essential to human health.
The sterol regulatory element–binding proteins (SREBPs) are key transcription regulators of …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …

The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating …

The recognition that the increase of plasma triglyceride rich lipoproteins (TRLs) is
associated with multiple alterations of other lipoproteins species that are potentially …

Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise
HDL levels have remained elusive. Recent advances in the understanding of lipid …

Specialized functions of macrophages have evolved to protect the body from infection.
However, the same mechanisms that enable phagocytosis of pathogens and activation of …

In recent studies we demonstrated that systemic levels of protein-bound nitrotyrosine
(NO2Tyr) and myeloperoxidase (MPO), a protein that catalyzes generation of nitrating …