Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société …
R Guilhaumou, S Benaboud, Y Bennis… - Critical Care, 2019 - Springer
Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
Pharmacokinetics–pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients
RP Veiga, JA Paiva - Critical Care, 2018 - Springer
Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …
management of critically ill patients and beta-lactams are the most common antibiotic class …
Applications of the pharmacokinetic/pharmacodynamic (PK/PD) analysis of antimicrobial agents
E Asín-Prieto, A Rodríguez-Gascón, A Isla - Journal of Infection and …, 2015 - Elsevier
The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …
Recommendation of antimicrobial dosing optimization during continuous renal replacement therapy
L Li, X Li, Y Xia, Y Chu, H Zhong, J Li, P Liang… - Frontiers in …, 2020 - frontiersin.org
Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients
for various indications recent years. It is still intricate for clinicians to decide a suitable …
for various indications recent years. It is still intricate for clinicians to decide a suitable …
Clinical implications of antibiotic pharmacokinetic principles in the critically ill
AA Udy, JA Roberts, J Lipman - Intensive care medicine, 2013 - Springer
Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …
Antibiotic dosing for critically ill adult patients receiving intermittent hemodialysis, prolonged intermittent renal replacement therapy, and continuous renal replacement …
BM Hoff, JH Maker, WE Dager… - Annals of …, 2020 - journals.sagepub.com
Objective: To summarize current antibiotic dosing recommendations in critically ill patients
receiving intermittent hemodialysis (IHD), prolonged intermittent renal replacement therapy …
receiving intermittent hemodialysis (IHD), prolonged intermittent renal replacement therapy …
Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?
IK Delattre, FS Taccone, F Jacobs, M Hites… - Expert review of anti …, 2017 - Taylor & Francis
Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …
the percentage of the dosing interval (% T) during which their free serum concentration …
Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation
K Shekar, MH Abdul-Aziz, V Cheng… - American journal of …, 2023 - atsjournals.org
Rationale: Data suggest that altered antimicrobial concentrations are likely during
extracorporeal membrane oxygenation (ECMO). Objectives: The primary aim of this analysis …
extracorporeal membrane oxygenation (ECMO). Objectives: The primary aim of this analysis …
Beta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy
Although early and appropriate antibiotic therapy remains the most important intervention for
successful treatment of septic shock, data guiding optimization of beta-lactam prescription in …
successful treatment of septic shock, data guiding optimization of beta-lactam prescription in …
Validation of a simple and economic HPLC-UV method for the simultaneous determination of vancomycin, meropenem, piperacillin and tazobactam in plasma …
Critically ill patients are often affected by several pathophysiological conditions requiring
antibiotic administration and, frequently, extracorporeal therapy that significantly alter the …
antibiotic administration and, frequently, extracorporeal therapy that significantly alter the …