Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …

Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients
for various indications recent years. It is still intricate for clinicians to decide a suitable …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Objective: To summarize current antibiotic dosing recommendations in critically ill patients
receiving intermittent hemodialysis (IHD), prolonged intermittent renal replacement therapy …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

Rationale: Data suggest that altered antimicrobial concentrations are likely during
extracorporeal membrane oxygenation (ECMO). Objectives: The primary aim of this analysis …

Although early and appropriate antibiotic therapy remains the most important intervention for
successful treatment of septic shock, data guiding optimization of beta-lactam prescription in …

Critically ill patients are often affected by several pathophysiological conditions requiring
antibiotic administration and, frequently, extracorporeal therapy that significantly alter the …