Friend or foe? Defining the role of glutamate in aging and Alzheimer's disease
Aging is a naturally occurring decline of physiological processes and biological pathways
that affects both the structural and functional integrity of the body and brain. These …
that affects both the structural and functional integrity of the body and brain. These …
The hippocampus associated GABAergic neural network impairment in early-stage of Alzheimer's disease
Y Tang, Y Yan, J Mao, J Ni, H Qing - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) is the commonest neurodegenerative disease with slow
progression. Pieces of evidence suggest that the GABAergic system is impaired in the early …
progression. Pieces of evidence suggest that the GABAergic system is impaired in the early …
Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer's disease neuropathologic change
Individuals at distinct stages of Alzheimer's disease (AD) show abnormal
electroencephalographic activity, which has been linked to network hyperexcitability and …
electroencephalographic activity, which has been linked to network hyperexcitability and …
Theta and gamma oscillatory dynamics in mouse models of Alzheimer's disease: A path to prospective therapeutic intervention
SF Mehak, AB Shivakumar, S Kumari… - Neuroscience & …, 2022 - Elsevier
Understanding the neural basis of cognitive deficits, a key feature of Alzheimer's disease
(AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in …
(AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in …
A multi-scale model explains oscillatory slowing and neuronal hyperactivity in Alzheimer's disease
CG Alexandersen, W de Haan… - Journal of the Royal …, 2023 - royalsocietypublishing.org
Alzheimer's disease is the most common cause of dementia and is linked to the spreading of
pathological amyloid-β and tau proteins throughout the brain. Recent studies have …
pathological amyloid-β and tau proteins throughout the brain. Recent studies have …
[HTML][HTML] Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease
L Melgosa-Ecenarro, N Doostdar, CI Radulescu… - Seminars in cell & …, 2023 - Elsevier
The early stages of Alzheimer's disease (AD) have been linked to microcircuit dysfunction
and pathophysiological neuronal firing in several brain regions. Inhibitory GABAergic …
and pathophysiological neuronal firing in several brain regions. Inhibitory GABAergic …
Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice
AJ Barbour, S Gourmaud, E Lancaster, X Li… - Brain, 2024 - academic.oup.com
Approximately 22% of Alzheimer's disease (AD) patients suffer from seizures, and the co-
occurrence of seizures and epileptiform activity exacerbates AD pathology and related …
occurrence of seizures and epileptiform activity exacerbates AD pathology and related …
Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer's
In Alzheimer's disease (AD), a multitude of genetic risk factors and early biomarkers are
known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD …
known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD …
An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission
Alzheimer's disease (AD) is a progressive neurodegenerative disease. The accumulation of
amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the key players responsible for …
amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the key players responsible for …
Aberrant serotonergic signaling contributes to the hyperexcitability of CA1 pyramidal neurons in a mouse model of Alzheimer's disease
J Wang, Y Mei, X Zhang, X Wei, Y Zhang, D Wang… - Cell Reports, 2023 - cell.com
Hyperactivity of pyramidal neurons (PNs) in CA1 is an early event in Alzheimer's disease.
However, factors accounting for the hyperactivity of CA1 PNs remain to be completely …
However, factors accounting for the hyperactivity of CA1 PNs remain to be completely …