Synopsis Lisinopril is an orally active angiotensin-converting enzyme (ACE) inhibitor which
at dosages of 20 to 80mg once daily is effective in lowering blood pressure in all grades of …

The orally active angiotensin-converting inhibitors (ACE inhibitors) such as captopril and
enalapril represent a significant therapeutic advance in the treatment of hypertension and …

The chemistry, pharmacology, pharmacokinetics, adverse effects, and dosages of the three
currently available angiotensin-converting enzyme (ACE) inhibitors are reviewed. This class …

BACKGROUND Serum angiotensin-converting enzyme (ACE) levels may be decreased by
use of ACE inhibitor (ACEI) medication. In this study, we determined how often ACE levels …

Crystallography is frequently used as follow-up method to validate hits identified by
biophysical screening cascades. The capacity of crystallography to directly screen fragment …

Objectives To investigate the efficacy and safety of fosinopril in the treatment of chronic heart
failure (CHF), patients with mild to moderate CHF and left ventricular ejection fractions< 40 …

The inter-relationship between the pharmacokinetic and pharmacodynamic behaviour of
ACE inhibitors is reviewed. First, some of the methods which have been used to assess the …

In 1898 Tigerstadt and Bergman showed that kidney extract exerted a potent pressor
response; in 1934 Goldblatt et al. developed an animal model of hypertension by the …

1. The population pharmacokinetics of lisinopril were investigated using data collected from
two multicentre trials of lisinopril in the treatment of hypertension in elderly patients (n= 40) …

The bioequivalence of two brands of lisinopril 20 mg tablets was demonstrated in 28 healthy
human volunteers after a single oral dose in a randomized cross‐over study, conducted at …