Histone proteins bind DNA and organize the genomes of eukaryotes and most archaea,
whereas bacteria rely on different nucleoid-associated proteins. Homology searches have …

Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their
large genomes into viral capsids is mostly unknown. The major capsid protein and the …

The three domains of life employ various strategies to organize their genomes. Archaea
utilize features similar to those found in both eukaryotic and bacterial chromatin to organize …

Telomeres, the ends of eukaryotic chromosomes, play pivotal parts in ageing and cancer
and are targets of DNA damage and the DNA damage response,,,–. Little is known about the …

The organization of genomic DNA into defined nucleosomes has long been viewed as a
hallmark of eukaryotes. This paradigm has been challenged by the identification of" …

Certain large DNA viruses, including those in the Marseilleviridae family, encode histones.
Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally …

In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B
that assemble into octameric nucleosome particles. Archaeal histones are dimeric and …

Histones compact and store DNA in both Eukarya and Archaea, forming heterodimers in
Eukarya and homodimers in Archaea. Despite this, the folding mechanism of histones …

Exchanging core histones in the nucleosome for paralogous variants can have important
functional ramifications. Many of these variants, and their physiological roles, have been …

Histone proteins compact and organize DNA resulting in a dynamic chromatin architecture
impacting DNA accessibility and ultimately gene expression. Eukaryotic chromatin …