Most human Siglecs (sialic acid binding immunoglobulin-like lectins) are expressed on the
surfaces of overlapping subsets of immune cells, and most carry immunoreceptor tyrosine …

Advances in immunotherapy have revolutionized cancer treatment, yet many patients do not
show clinical responses. While most immunotherapies target T cells, myeloid cells are the …

Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging
cancer immunotherapy target. However, limited understanding of its structure and …

Fucose in fucosylated glycans is primarily assembled at multiple sets of N-acetyllactosamine
(LN) and lacto-N-biose (LNB) units, which are known as Lewis antigens. The synthesis of …

All cells are decorated with complex carbohydrate structures called glycans that serve as
ligands for glycan-binding proteins (GBPs) to mediate a wide range of biological processes …

Nucleotide sugars play an elementary role in nature as building blocks of glycans,
polysaccharides, and glycoconjugates used in the pharmaceutical, cosmetics, and food …

Glycosylation is one of the most common post-translational modifications of proteins, which
plays essential roles in regulating the biological functions of proteins. Efficient and versatile …

Exo-enzymatic glycan labeling strategies have emerged as versatile tools for efficient and
selective installation of terminal glyco-motifs onto live cell surfaces. Through employing …

Xylans are a diverse family of hemicellulosic polysaccharides found in abundance within the
cell walls of nearly all flowering plants. Unfortunately, naturally occurring xylans are highly …

While the field of biocatalysis has bloomed over the past 20–30 years, advances in the
understanding and improvement of carbohydrate-active enzymes, in particular, the sugar …