Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as
cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term …

Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …

Acute myocardial infarction (MI) is the leading cause of death worldwide. Exogenous
delivery of nitric oxide (NO) to the infarcted myocardium has proven to be an effective …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS, eg nitric oxide, NO) are
well recognised for playing a dual role as both deleterious and beneficial species. ROS and …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves
mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results …

The discovery of leptin in 1994 sparked dramatic new interest in the study of white adipose
tissue. It is now recognised to be a metabolically active endocrine organ, producing …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …