Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

Our respiratory system is exposed to toxicants and pathogens from both sides: the airways
and the vasculature. While tracheal, bronchial and alveolar epithelial cells form a natural …

Transient receptor potential (TRP) channel TRPV4 is a polymodal cellular sensor that
responds to moderate heat, cell swelling, shear stress, and small-molecule ligands. It is …

Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but
often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid …

Background A range of neurological pathologies may lead to secondary hydrocephalus.
Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as …

The transient receptor potential (TRP) channel superfamily consists of a large group of non-
selective cation channels that serve as cellular sensors for a wide spectrum of physical and …

The transient receptor potential vanilloid 4 (TRPV4) channel is a non-selective cation
channel that is mostly permeable to calcium (Ca2+), which participates in intracellular Ca2+ …

The transient receptor potential vanilloid 4 channel (TRPV4) is a non-selective cation
channel that is widely expressed and activated by a range of stimuli. Amongst these stimuli …

Fibrosis is an irreversible, debilitating condition marked by the excessive production of
extracellular matrix and tissue scarring that eventually results in organ failure and disease …

The choroid plexus is a small monolayered epithelium located in the brain ventricles and
serves to secrete the cerebrospinal fluid (CSF) that envelops the brain and fills the central …