Recent advances in systemic and locoregional treatments for patients with unresectable or
advanced hepatocellular carcinoma (HCC) have resulted in improved response rates. This …

The capability of the liver to fully regenerate after injury is a unique phenomenon essential
for the maintenance of its important functions in the control of metabolism and xenobiotic …

Background Patients with colorectal liver metastases (CLM) are increasingly treated with
preoperative chemotherapy. Chemotherapy associated liver injury is associated with …

Objective This study was designed to evaluate the long-time outcome of patients with
colorectal liver metastasis (CRLM) undergoing different types of therapy and identify …

Evolution in the treatment of metastatic colorectal cancer (mCRC) has led to significant
improvement in the survival of these patients. Surgery is useful in patients with resectable …

Colorectal cancer (CRC) is the third most common cancer in the word. Liver metastasis is
the most common site of colorectal metastases. The prognosis of resectable colorectal liver …

The purpose of this study was to identify early circulating metabolite changes implicated in
the mechanism of action of irinotecan, a DNA topoisomerase I inhibitor, in cancer patients. A …

BACKGROUND: Patients undergoing liver resection for colorectal cancer liver metastasis
(CRCLM) are often treated with chemotherapy before surgery. However, the associations …

The development of effective therapies for the prevention of colorectal cancer (CRC) liver
metastasis is of great importance. Recently, chitosan (CS) nanoparticles have been utilized …

Background & Aims The liver performs a panoply of complex activities coordinating
metabolic, immunologic and detoxification processes. Despite the liver's robustness and …