Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …

The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Mycobacterium tuberculosis complex causes tuberculosis (TB), one of the top 10 causes of
death worldwide. TB results in more fatalities than multi-drug resistant (MDR) HIV strain …

The development of human vaccines continues to rely on the use of animals for research.
Regulatory authorities require novel vaccine candidates to undergo preclinical assessment …

Tuberculous meningitis (TBM), the most devastating manifestation of tuberculosis, is often
missed or overlooked because of nonspecific symptoms and difficulties in diagnosis. It …

Background Tuberculosis (TB) remains a leading cause of death worldwide, with 98% of
cases occurring in low-and middle-income countries (LMICs). The only vaccine licenced for …

Tuberculosis (TB) is an infectious disease that seriously affects human health. Until now, the
only anti-TB vaccine approved for use is the live attenuated Mycobacterium bovis (M. bovis) …

Substantial efforts have been made over the past decade to develop vaccines against
tuberculosis. We review recent developments in tuberculosis vaccines in the global portfolio …

The development of a vaccine for Mycobacterium tuberculosis (Mtb) has been impeded by
the absence of correlates of protective immunity. One correlate would be the ability of cells …

In order to develop an improved BCG vaccine against tuberculosis we have taken
advantage of the adjuvant properties of a non-toxic derivative of Escherichia coli heat labile …