Simple Summary The management of rectal cancer has become increasingly more complex.
Over the recent year, the use of chemotherapy and radiation before surgical intervention has …

Aim The aim was to evaluate the association of neoadjuvant therapy with increases in the
incidence of anastomotic leakage (AL) after middle and low rectal anterior resection. Method …

Purpose This guideline reviews the evidence and provides recommendations for the
indications and appropriate technique and dose of neoadjuvant radiation therapy (RT) in the …

Purpose Whether preoperative chemoradiotherapy (CRT) is better than postoperative CRT
in oncologic outcome and toxicity is contentious in prospective randomized clinical trials. We …

The use of multimodal treatments for rectal cancer has improved cancer-related outcomes
but makes monitoring toxicity challenging. Optimizing future radiation therapy regimens …

Sarcopenia is associated with low muscle mass and low physical performance. Here, we
performed to evaluate the sarcopenia as prognostic factor and treatment outcomes in older …

Background and Aims: The aim of this study was to analyse the landscape of publications on
rectal cancer (RC) over the past 25 years by machine learning and semantic analysis …

CRLX101 is a nanoparticle-drug conjugate with a camptothecin payload. We assessed the
toxicity and pathologic complete response (pCR) rate of CRLX101 with standard …

Objective. Neoadjuvant radiotherapy (nRT) is an important treatment approach for rectal
cancer. The relationship, however, between nRT and postoperative complications is still …

This was a phase II study of capecitabine in substitution of 5-fluorouracil (5-FU) in the
chemoradiotherapy regimen for patients with localized squamous cell carcinoma of the anal …