The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

APOBEC proteins can deaminate cytosine residues in DNA and RNA. This can lead to
somatic mutations, DNA breaks, RNA modifications, or DNA demethylation in a selective …

Despite the rapid advancement in the introduction of new drugs for cancer therapy, the
frequent emergence of drug resistance leads to disease progression or tumor recurrence …

Purpose To develop and externally validate models incorporating a PET radiomics signature
(R-signature) obtained by the cross-combination method for predicting the survival of …

Despite selective HDAC3 inhibition showing promise in a subset of lymphomas with
CREBBP mutations, wild-type tumors generally exhibit resistance. Here, using unbiased …

Epidemiological evidence supports an association between cow's milk consumption and the
risk of diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma …

The fate of pyruvate is a defining feature in many cell types. One major fate is mitochondrial
entry via the mitochondrial pyruvate carrier (MPC). We found that diffuse large B cell …

Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous
disease that requires personalized clinical treatment. To assign patients into different risk …

Genetic abnormalities in histone methyltransferases (HMTs) frequently occur in diffuse large
B-cell lymphoma (DLBCL) and are related to its progression. SET and MYND domain …

Enhancer of zeste homolog 2 (EZH2) is an epigenetic regulator that controls the normal
biology of germinal B cells. Overexpression or mutation of EZH2 is associated with …