Gram-negative bacteria express a plethora of efflux pumps that are capable of transporting
structurally varied molecules, including antibiotics, out of the bacterial cell. This efflux lowers …

Combination antibiotic therapy for invasive infections with Gram-negative bacteria is
employed in many health care facilities, especially for certain subgroups of patients …

Land application of animal manures is a major dissemination route for antibiotic resistance
genes (ARGs) in agro-ecosystems, which are a potential risk to public health if they migrate …

Since the introduction of penicillin, β-lactam antibiotics have been the antimicrobial agents
of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened …

Acinetobacter baumannii is an emerging pathogen that poses a global health threat due to a
lack of therapeutic options for treating drug-resistant strains. In addition to acquiring …

Abstract The Infectious Diseases Society of America (IDSA) continues to view with concern
the lean pipeline for novel therapeutics to treat drug-resistant infections, especially those …

Acinetobacter baumannii is increasingly associated with various epidemics, representing a
serious concern due to the broad level of antimicrobial resistance and clinical …

Acinetobacter baumannii has emerged as a highly troublesome pathogen for many
institutions globally. As a consequence of its immense ability to acquire or upregulate …

The rapid expansion of Acinetobacter baumannii clinical isolates exhibiting resistance to
carbapenems and most or all available antibiotics during the last decade is a worrying …

Carbapenems, once considered the last line of defense against of serious infections with
Enterobacteriaceae, are threatened with extinction. The increasing isolation of carbapenem …