Carbapenem resistance in Acinetobacter baumannii: laboratory challenges, mechanistic insights and therapeutic strategies

I Abbott, GM Cerqueira, S Bhuiyan… - Expert review of anti …, 2013 - Taylor & Francis
Unprecedented levels of antimicrobial resistance in bacterial isolates have prompted great
concerns globally. In 2012 the WHO released a publication outlining the evolving threat of …

Management of meningitis due to antibiotic-resistant Acinetobacter species

BN Kim, AY Peleg, TP Lodise, J Lipman, J Li… - The Lancet infectious …, 2009 - thelancet.com
Acinetobacter meningitis is becoming an increasingly common clinical entity, especially in
the postneurosurgical setting, with mortality from this infection exceeding 15%. Infectious …

Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

L Poirel, RA Bonnin, P Nordmann - IUBMB life, 2011 - Wiley Online Library
Antibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is
increasing rapidly. A. baumannii possesses two intrinsic β‐lactamase genes, in addition to …

[HTML][HTML] Enhanced antibacterial effect of the novel T4-like bacteriophage KARL-1 in combination with antibiotics against multi-drug resistant Acinetobacter baumannii

M Jansen, A Wahida, S Latz, A Krüttgen, H Häfner… - Scientific reports, 2018 - nature.com
The continuing rise of infections caused by multi-drug resistant bacteria has led to a
renewed interest in bacteriophage therapy. Here we characterize phage vB_AbaM-KARL-1 …

Acinetobacter in veterinary medicine, with an emphasis on Acinetobacter baumannii

JH van der Kolk, A Endimiani, C Graubner… - Journal of global …, 2019 - Elsevier
Acinetobacter spp. are aerobic, rod-shaped, Gram-negative bacteria belonging to the
Moraxellaceae family of the class Gammaproteobacteria and are considered ubiquitous …

Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents

SA Rogers, RW Huigens III, J Cavanagh… - Antimicrobial agents …, 2010 - Am Soc Microbiol
Aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit
and disperse biofilms across bacterial order, class, and phylum. Herein, we report the …

Activity of meropenem combined with RPX7009, a novel β-lactamase inhibitor, against Gram-negative clinical isolates in New York City

A Lapuebla, M Abdallah, O Olafisoye… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Multidrug-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing
Enterobacteriaceae are endemic to hospitals in New York City and other regions. RPX7009 …

Defining gene-phenotype relationships in Acinetobacter baumannii through one-step chromosomal gene inactivation

AT Tucker, EM Nowicki, JM Boll, GA Knauf, NC Burdis… - MBio, 2014 - Am Soc Microbiol
Rates of infection with hospital-acquired Acinetobacter baumannii have exploded over the
past decade due to our inability to limit persistence and effectively treat disease. A …

The effect of silver or gallium doped titanium against the multidrug resistant Acinetobacter baumannii

A Cochis, B Azzimonti, C Della Valle, E De Giglio… - Biomaterials, 2016 - Elsevier
Implant-related infection of biomaterials is one of the main causes of arthroplasty and
osteosynthesis failure. Bacteria, such as the rapidly-emerging Multi Drug Resistant (MDR) …

[HTML][HTML] Active and Passive Immunization Protects against Lethal, Extreme Drug Resistant-Acinetobacter baumannii Infection

G Luo, L Lin, AS Ibrahim, B Baquir, P Pantapalangkoor… - PloS one, 2012 - journals.plos.org
Extreme-drug-resistant (XDR) Acinetobacter baumannii is a rapidly emerging pathogen
causing infections with unacceptably high mortality rates due to inadequate available …