Objectives The aim of this study was to evaluate the occurrence and dissemination of
acquired carbapenem-hydrolysing class D β-lactamase (class D carbapenemase)-and …

Objectives bloodstream infections (BSI) due to multidrug-resistant (MDR) Acinetobacter
baumannii (AB) have been increasingly observed among hospitalized patients. Methods …

ABSTRACT A total of 49 unique clinical isolates of multidrug-resistant (MDR) Acinetobacter
baumannii identified at a tertiary medical center in Pittsburgh, Pennsylvania, between …

The emergence of extremely resistant and panresistant Gram-negative bacilli, such as
Acinetobacter baumannii, requires consideration of nonantimicrobial therapeutic …

Carbapenem resistance results mostly from the expression of acquired carbapenem-
hydrolyzing oxacillinases in Acinetobacter baumannii. The bla OXA-23 oxacillinase gene is …

In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named
AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to …

Carbapenemases are β-lactamase enzymes that hydrolyze a variety of β-lactams including
carbapenem and belong to different Ambler classes (A, B, D). These enzymes can be …

Introduction Severe pneumonia caused by multidrug-resistant Acinetobacter baumannii
(MDR-AB) remains a difficult-to-treat infection. Considering the poor lung penetration of most …

Background Acinetobacter baumannii infection is a serious public health problem because it
is highly resistant to antimicrobial therapy and causes a high fatality rate in critically ill …

New treatments are needed for extensively drug-resistant (XDR) Gram-negative bacilli
(GNB), such as Acinetobacter baumannii. Toll-like receptor 4 (TLR4) was previously …