Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Acanthosis nigricans (AN) has been reported in relation to insulin resistance (IR). We aim to
review AN through an endocrine and metabolic perspective focusing on IR in association …

Objective Underdiagnosis is an important issue in genetic lipodystrophies, which are rare
diseases with metabolic, cardiovascular, gynecological, and psychological complications …

Celia's encephalopathy or progressive encephalopathy with/without lipodystrophy is a
neurodegenerative disease with a fatal prognosis in childhood. It is generally caused by the …

Context The diagnosis of familial partial lipodystrophy (FPLD) is currently made based on
clinical judgment. Objective There is a need for objective diagnostic tools that can diagnose …

Pediatric nonalcoholic fatty liver disease (NAFLD) represents a spectrum of chronic liver
disease that can range from isolated steatosis Nonalcoholic Fatty Liver (NAFL) …

Body fat distribution is a predictor of metabolic health in obesity. In this Classics in Diabetes
article, we revisit a 1985 Diabetes article by Swedish investigators Ohlson et al. This work …

Aims Individuals with lipodystrophies typically suffer from metabolic disease linked to
adipose tissue dysfunction including lipoatrophic diabetes. In the most severe forms of …

Adipose tissue encompasses various types, including White Adipose Tissue (WAT), Brown
Adipose Tissue (BAT), and beige adipose tissue, each having distinct roles in energy …

Context In the last decade the Sanger method of DNA sequencing has been replaced by
next-generation sequencing (NGS). NGS is valuable in conditions characterized by high …