Major advances in genetic and epigenetic profiling of acute lymphoblastic leukaemia (ALL)
have enhanced the understanding of key biological subsets of de novo and relapsed ALL …

Aberrant alternative splicing of pre-mRNA is an emerging cancer hallmark. Many cancer-
associated genes undergo alternative splicing to produce multiple isoforms with diverse or …

More than 50% of myeloma cases have normal karyotypes under conventional cytogenetic
analysis due to low mitotic activity and content of plasma cells in the bone marrow. We used …

The ubiquitously expressed phosphatidylinositol binding clathrin assembly (PICALM)
protein associates with the plasma membrane, binds clathrin, and plays a role in clathrin …

The prognostic impact of PICALM:: MLLT10 status in childhood leukaemia is not well
described. Ten International Berlin Frankfurt Münster‐affiliated study groups and the …

CALM-AF10 (also known as PICALM-MLLT10) is the commonest fusion protein in T-cell
acute lymphoblastic leukemia, but its prognostic impact remains unclear. Molecular …

PICALM:: MLLT10 fusion is a rare but recurrent genetic driver in acute leukemias. To better
understand the genomic landscape of PICALM:: MLLT10 (PM) positive acute leukemia, we …

Rearrangements of the MLLT10 gene occur in acute myeloid leukemia (AML) and acute
lymphoblastic leukemia (ALL), most commonly T‐lineage ALL (T‐ALL), in patients of all …

Acute myeloid leukemia (AML) is a heterogeneous group of hematologic malignancies
characterized by the proliferation of myeloid cells blocked in their ability to differentiate …

Recurrent gene rearrangements result in gene fusions that encode chimeric proteins, driving
the pathogenesis of many hematologic neoplasms. The fifth edition World Health …