Background Sepsis is a global health challenge associated with significant morbidity and
mortality. Detrimental sepsis effects are attributed to excessive inflammation or a “cytokine …

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to
infection, is a leading cause of death in intensive care units. The development of sepsis …

Cardiovascular disease (CAD) is the main cause of morbidity and deaths in the western
world. The development of atherosclerosis underlying CAD development begins early in …

Background Over-activation of the NLRP3 inflammasome can lead to sepsis. NLRP3 is an
essential protein in the classical pathway of pyroptosis. This study assessed the use of …

Background The mortality rate of patients with sepsis has been increasing in recent years.
Alterations of biomarkers levels during treatment are important in evaluating treatment …

Sepsis triggers a complex response marked by the simultaneous presence of
proinflammatory and immunosuppressive elements, disrupting the mechanisms intended to …

Excessive release of cytokines such as IL‐1β and other inflammatory mediators synthesized
and secreted by macrophages is the fundamental link of uncontrolled inflammatory …

Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host
immune response to infection. Immune response induced by sepsis is complex and …

Macrophages infiltration is a crucial factor causing Sepsis-associated acute lung injury (ALI).
Accumulating evidence suggests macrophages-alveolar epithelial cells communication is …

Pyroptosis is a form of caspase-1-induced programmed cell death. This study aimed to
investigate the effect of periostin (postn) on pyroptosis in myocardial ischemia-reperfusion …