The increased utilization of high-risk renal grafts for transplantation requires optimization of
pretransplant organ assessment strategies. Current decision-making methods to accept an …

The final decision to accept an organ for transplantation remains a subjective one. With
“poor organ quality” commonly cited as a major reason for kidney discard, accurate …

Background. Better preservation strategies for the storage of donation after circulatory death
grafts are essential to improve graft function and to increase the kidney donor pool. We …

Normothermic machine perfusion presents a novel platform for pretransplant assessment
and reconditioning of kidney grafts. Maintaining the metabolic activity of a preserved graft at …

Donor organ shortage still remains a serious obstacle for the access of wait-list patients to
kidney transplantation, the best treatment for End-Stage Kidney Disease (ESKD). To expand …

Transplantation medicine is a rapidly evolving field. Keeping afloat of the published
literature to offer the best clinical care to our patients is a daunting task. As part of its …

Background. Normothermic machine perfusion (NMP) may allow resuscitation and improved
assessment of kidneys before transplantation. Using discarded human kidneys, we …

Hypothermic machine perfusion (HMP) has become the new gold standard in clinical donor
kidney preservation and a promising novel strategy in higher risk donor livers in several …

Hypothermic oxygenated machine perfusion (HOPE) was recently tested in preclinical trials
in kidney transplantation (KT). Here we investigate the effects of HOPE on extended-criteria …

Background Ischaemia-reperfusion (IR) injury makes a major contribution to graft damage
during kidney transplantation. Oxidative damage to mitochondria is an early event in IR …