The neuropeptide oxytocin has emerged as a promising pharmacotherapy for
methamphetamine (METH) addiction, and clinical trials of intranasal oxytocin are underway …

Repeated drug use has long-lasting effects on plasticity throughout the brain's reward and
memory systems. Environmental cues that are associated with drugs of abuse can elicit …

The neural circuitry underlying mammalian reward behaviors involves several distinct nuclei
throughout the brain. It is widely accepted that the midbrain dopamine (DA) neurons are …

Addiction to drug and alcohol is regarded as a major health problem worldwide for which
available treatments show limited effectiveness. The biggest challenge remains to enhance …

Studies using the renewal procedure showed that basolateral amygdala (BLA) inactivation
inhibits context-induced relapse to cocaine-seeking after extinction. Here, we determined …

Methamphetamine (METH) abuse is characterised by chronic relapse and anxiety, for which
there are no effective pharmacotherapies. Acute treatment with the neuropeptide oxytocin …

Cue-induced drug craving and seeking progressively increases during abstinence. This
“incubation of drug craving” phenomenon has been observed in both laboratory animals …

The central amygdala (CeA) with its medial (CeM) and lateral (CeL) nuclei is the brain hub
for processing stimuli with emotional context. CeL nucleus gives a strong inhibitory input to …

Approximately 25% of patients who are prescribed opioids for chronic pain misuse them,
and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids …

Many studies have demonstrated that negative allosteric modulators (NAM) of metabotropic
glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction …