Role of orbitofrontal cortex in incubation of oxycodone craving in male rats

RD Altshuler, ES Yang, KT Garcia, IR Davis… - Addiction …, 2021 - Wiley Online Library
One of the main challenges in treating opioid‐use disorders is relapse during abstinence,
triggered by re‐exposure to drug‐associated cues. Previous studies have demonstrated that …

Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking

D Roura‐Martínez, M Ucha, J Orihuel… - Addiction …, 2020 - Wiley Online Library
Relapse into drug use is a major problem faced by recovering addicts. In humans, an
intensification of the desire for the drug induced by environmental cues—incubation of drug …

Role of piriform cortex and its afferent projections in relapse to fentanyl seeking after food choice-induced voluntary abstinence

SM Claypool, DJ Reiner, S Behdin… - Journal of …, 2023 - Soc Neuroscience
We previously demonstrated a role of piriform cortex (Pir) in relapse to fentanyl seeking after
food choice-induced voluntary abstinence. Here, we used this model to further study the role …

Role of anterior intralaminar nuclei of thalamus projections to dorsomedial striatum in incubation of methamphetamine craving

X Li, KR Witonsky, OM Lofaro, F Surjono… - Journal of …, 2018 - Soc Neuroscience
Relapse to methamphetamine (Meth) seeking progressively increases after withdrawal from
drug self-administration (incubation of Meth craving). We previously demonstrated a role of …

Optogenetic activation of the central amygdala generates addiction‐like preference for reward

RL Tom, A Ahuja, H Maniates… - European Journal of …, 2019 - Wiley Online Library
Drug and behavioural addictions are characterized by an intense and focused pursuit of a
single reward above all others. Pursuit of the addictive reward is often compulsively sought …

Incubation of extinction responding and cue‐induced reinstatement, but not context‐or drug priming‐induced reinstatement, after withdrawal from methamphetamine

S Adhikary, D Caprioli, M Venniro… - Addiction …, 2017 - Wiley Online Library
In rats trained to self‐administer methamphetamine, extinction responding in the presence of
drug‐associated contextual and discrete cues progressively increases after withdrawal …

GABA-induced inactivation of dorsal midline thalamic subregions has distinct effects on emotional behaviors

JR Barson, SF Leibowitz - Neuroscience letters, 2015 - Elsevier
The paraventricular nucleus of the thalamus (PVT) is a key node integrating information
about emotion and relaying output to other limbic structures influencing motor behavior. With …

Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self …

D Roura-Martínez, P Díaz-Bejarano, M Ucha… - …, 2020 - Elsevier
Relapse into drug use is a significant problem for people recovering from addiction. The
ability that conditioned cues have to reinstate and reinvigorate drug-seeking is potentiated …

Self-administration of entactogen psychostimulants dysregulates gamma-aminobutyric acid (GABA) and kappa opioid receptor signaling in the central nucleus of the …

S Khom, JD Nguyen, SA Vandewater… - Frontiers in Behavioral …, 2021 - frontiersin.org
Male rats escalate intravenous self-administration of entactogen psychostimulants, 3, 4-
methylenedioxymethcathinone (methylone) and 3, 4-methylenedioxymethamphetamine …

Genome-wide transcriptional profiling of central amygdala and orbitofrontal cortex during incubation of methamphetamine craving

HM Cates, X Li, I Purushothaman… - …, 2018 - nature.com
Methamphetamine (Meth) seeking progressively increases after withdrawal (incubation of
Meth craving), but the transcriptional mechanisms that contribute to this incubation are …