Skin barrier abnormalities and immune dysfunction in atopic dermatitis
Atopic dermatitis (AD) is a common and relapsing skin disease that is characterized by skin
barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to …
barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to …
The genetics and epigenetics of atopic dermatitis—filaggrin and other polymorphisms
Y Liang, C Chang, Q Lu - Clinical reviews in allergy & immunology, 2016 - Springer
Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by a combination of
genetic and environmental factors. Genetic evidences depict a complex network comprising …
genetic and environmental factors. Genetic evidences depict a complex network comprising …
Current insights into immunology and novel therapeutics of atopic dermatitis
HA Kader, M Azeem, SA Jwayed, A Al-Shehhi… - Cells, 2021 - mdpi.com
Atopic dermatitis (AD) is one of the most prevalent inflammatory disease among non-fatal
skin diseases, affecting up to one fifth of the population in developed countries. AD is …
skin diseases, affecting up to one fifth of the population in developed countries. AD is …
An update on the pathophysiology of atopic dermatitis
K Malik, KD Heitmiller, T Czarnowicki - Dermatologic Clinics, 2017 - derm.theclinics.com
AD is a complex, multifactorial disease. Immune dysregulation, barrier impairment, microbial
shifts, environmental factors, and genetic propensity all orchestrate the disease phenotype …
shifts, environmental factors, and genetic propensity all orchestrate the disease phenotype …
Molecular mechanisms of cutaneous inflammatory disorder: atopic dermatitis
JE Kim, JS Kim, DH Cho, HJ Park - International journal of molecular …, 2016 - mdpi.com
Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …
[HTML][HTML] Early activation of Th2/Th22 inflammatory and pruritogenic pathways in acute canine atopic dermatitis skin lesions
T Olivry, D Mayhew, JS Paps, KE Linder… - Journal of Investigative …, 2016 - Elsevier
Determining inflammation and itch pathway activation in patients with atopic dermatitis (AD)
is fraught with the inability to precisely assess the age of skin lesions, thus affecting the …
is fraught with the inability to precisely assess the age of skin lesions, thus affecting the …
The complex type 2 endotype in allergy and asthma: from laboratory to bedside
Better management of allergic diseases needs a sharpened understanding of disease
heterogeneity and mechanisms in relation to clinically significant outcomes. Phenotypes …
heterogeneity and mechanisms in relation to clinically significant outcomes. Phenotypes …
TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents
L Wallmeyer, K Dietert, M Sochorová, AD Gruber… - Scientific reports, 2017 - nature.com
Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic
dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably …
dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably …
Human eosinophils and mast cells: Birds of a feather flock together
PA Robida, PG Puzzovio, H Pahima… - Immunological …, 2018 - Wiley Online Library
While the origin of the phrase “birds of a feather flock together” is unclear, it has been in use
for centuries and is typically employed to describe the phenomenon that people with similar …
for centuries and is typically employed to describe the phenomenon that people with similar …
Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis
W Wu, G Peng, F Yang, Y Zhang… - Molecular medicine …, 2019 - spandidos-publications.com
Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by intense
itching and recurrent eczematous lesions. Sulforaphane is known to attenuate oxidative …
itching and recurrent eczematous lesions. Sulforaphane is known to attenuate oxidative …