Clostridium difficile binary toxin CDT: Mechanism, epidemiology, and potential clinical importance
DN Gerding, S Johnson, M Rupnik, K Aktories - Gut microbes, 2014 - Taylor & Francis
Binary toxin (CDT) is frequently observed in Clostridium difficile strains associated with
increased severity of C. difficile infection (CDI). CDT belongs to the family of binary ADP …
increased severity of C. difficile infection (CDI). CDT belongs to the family of binary ADP …
Binary Bacterial Toxins: Biochemistry, Biology, and Applications of Common Clostridium and Bacillus Proteins
H Barth, K Aktories, MR Popoff… - … and Molecular Biology …, 2004 - Am Soc Microbiol
Certain pathogenic species of Bacillus and Clostridium have developed unique methods for
intoxicating cells that employ the classic enzymatic “AB” paradigm for protein toxins. The …
intoxicating cells that employ the classic enzymatic “AB” paradigm for protein toxins. The …
Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being
BG Stiles, K Pradhan, JM Fleming, RP Samy, H Barth… - Toxins, 2014 - mdpi.com
Some pathogenic spore-forming bacilli employ a binary protein mechanism for intoxicating
the intestinal tracts of insects, animals, and humans. These Gram-positive bacteria and their …
the intestinal tracts of insects, animals, and humans. These Gram-positive bacteria and their …
Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells
E Kaiser, S Pust, C Kroll, H Barth - Cellular microbiology, 2009 - Wiley Online Library
The binary Clostridium botulinum C2 toxin consists of the binding/translocation component
C2IIa and the separate enzyme component C2I, which mono‐ADP‐ribosylates actin in …
C2IIa and the separate enzyme component C2I, which mono‐ADP‐ribosylates actin in …
FK506‐binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells
E Kaiser, N Böhm, K Ernst, S Langer… - Cellular …, 2012 - Wiley Online Library
The binary Clostridium botulinum C2 toxin consists of the binding/translocation component
C2IIa and the separate enzyme component C2I. C2IIa delivers C2I into the cytosol of …
C2IIa and the separate enzyme component C2I. C2IIa delivers C2I into the cytosol of …
Clostridial binary toxins: iota and C2 family portraits
BG Stiles, DJ Wigelsworth, MR Popoff… - Frontiers in cellular and …, 2011 - frontiersin.org
There are many pathogenic Clostridium species with diverse virulence factors that include
protein toxins. Some of these bacteria, such as C. botulinum, C. difficile, C. perfringens, and …
protein toxins. Some of these bacteria, such as C. botulinum, C. difficile, C. perfringens, and …
[HTML][HTML] Pore-forming activity of clostridial binary toxins
O Knapp, R Benz, MR Popoff - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
Clostridial binary toxins (Clostridium perfringens Iota toxin, Clostridium difficile transferase,
Clostridium spiroforme toxin, Clostridium botulinum C2 toxin) as Bacillus binary toxins …
Clostridium spiroforme toxin, Clostridium botulinum C2 toxin) as Bacillus binary toxins …
Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins
K Ernst, S Langer, E Kaiser, C Osseforth… - Journal of molecular …, 2015 - Elsevier
Clostridium botulinum C2 toxin, Clostridium perfringens iota toxin and Clostridium difficile
CDT belong to the family of binary actin ADP-ribosylating toxins and are composed of a …
CDT belong to the family of binary actin ADP-ribosylating toxins and are composed of a …
Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen
L Dmochewitz, M Lillich, E Kaiser… - Cellular …, 2011 - Wiley Online Library
Bacillus anthracis lethal toxin consists of the protective antigen (PA) and the metalloprotease
lethal factor (LF). During cellular uptake PA forms pores in membranes of endosomes, and …
lethal factor (LF). During cellular uptake PA forms pores in membranes of endosomes, and …
Characterization and Pharmacological Inhibition of the Pore-Forming Clostridioides difficile CDTb Toxin
K Ernst, M Landenberger, J Nieland, K Nørgaard… - Toxins, 2021 - mdpi.com
The clinically highly relevant Clostridioides (C.) difficile releases several AB-type toxins that
cause diseases such as diarrhea and pseudomembranous colitis. In addition to the main …
cause diseases such as diarrhea and pseudomembranous colitis. In addition to the main …