[PDF][PDF] Mitochondrial signal transduction

M Picard, OS Shirihai - Cell metabolism, 2022 - cell.com
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction

AS Monzel, JA Enríquez, M Picard - Nature metabolism, 2023 - nature.com
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

[HTML][HTML] Mitochondria: It is all about energy

A Casanova, A Wevers, S Navarro-Ledesma… - Frontiers in …, 2023 - frontiersin.org
Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

[HTML][HTML] Emerging roles of brain metabolism in cognitive impairment and neuropsychiatric disorders

IM Morella, R Brambilla, L Morè - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Here we discuss the role of diverse environmental manipulations affecting cognition with
special regard to psychiatric conditions. We present evidence supporting a direct causal …

Oxytocin and oxygen: the evolution of a solution to the 'stress of life'

CS Carter, MA Kingsbury - Philosophical Transactions of …, 2022 - royalsocietypublishing.org
Oxytocin (OT) and the OT receptor occupy essential roles in our current understanding of
mammalian evolution, survival, sociality and reproduction. This narrative review examines …

[HTML][HTML] Powering the social brain: Mitochondria in social behaviour

DH Ülgen, SR Ruigrok, C Sandi - Current Opinion in Neurobiology, 2023 - Elsevier
A central role of brain mitochondria in regulating and influencing social behaviour is
emerging. In addition to its important roles as the “powerhouses” of the cell, mitochondria …

Why do we care more about disease than health?

M Picard - Phenomics, 2022 - Springer
Modern Western biomedical research and clinical practice are primarily focused on disease.
This disease-centric approach has yielded an impressive amount of knowledge around what …

[HTML][HTML] Dysfunctional mitochondrial processes contribute to energy perturbations in the brain and neuropsychiatric symptoms

P Büttiker, S Weissenberger, T Esch… - Frontiers in …, 2023 - frontiersin.org
Mitochondria are complex endosymbionts that evolved from primordial purple nonsulfur
bacteria. The incorporation of bacteria-derived mitochondria facilitates a more efficient and …

Molecular and immunological origins of catatonia

SR Beach, J Luccarelli, N Praschan, M Fusunyan… - Schizophrenia …, 2024 - Elsevier
Catatonia occurs secondary to both primary psychiatric and neuromedical etiologies.
Emerging evidence suggests possible linkages between causes of catatonia and …

[HTML][HTML] Mitochondrial and metabolic features of salugenesis and the healing cycle

RK Naviaux - Mitochondrion, 2023 - Elsevier
Pathogenesis and salugenesis are the first and second stages of the two-stage problem of
disease production and health recovery. Salugenesis is the automatic, evolutionarily …