SELEX (systematic evolution of ligands by exponential enrichment) is a process that
involves the progressive purification from a combinatorial library of nucleic acid ligands with …

Recent evidence suggests that gene expression may be regulated, at least in part, at post‐
transcriptional level by factors inducing the extremely rapid degradation of messenger …

RNA‐binding proteins HuR and AUF1 bind to many common AU‐rich target mRNAs and
exert opposing influence on target mRNA stability, but the functional interactions between …

More effective therapies are urgently needed against hepatitis C virus (HCV), a major cause
of viral hepatitis. We used in vitro protein expression and microfluidic affinity analysis to …

The Fox‐1 protein regulates alternative splicing of tissue‐specific exons by binding to
GCAUG elements. Here, we report the solution structure of the Fox‐1 RNA binding domain …

Hu proteins bind to adenosine-uridine (AU)-rich elements (AREs) in the 3′ untranslated
regions of many short-lived mRNAs, thereby stabilizing them. Here we report the crystal …

The RNA-binding protein HuR stabilizes labile mRNAs carrying AU-rich instability elements.
This mRNA stabilization can be induced by hypoxia, lipopolysaccharide, and UV light. The …

Aptamers are functional nucleic acids possessing high affinity and specificity to their cognate
ligands and are isolated from a library of nucleic acids by iterative rounds of selection and …

Human RNA-binding protein HuR, a nucleocytoplasmic shuttling protein, is a ubiquitously
expressed member of the family of Hu proteins, which consist of two N-terminal RNA …

During the last decade evidence has accumulated that modulation of mRNA stability plays a
central role in cellular homeostasis, including cell differentiation, proliferation and adaptation …