Towards clinical translation of FLASH radiotherapy

MC Vozenin, J Bourhis, M Durante - Nature Reviews Clinical Oncology, 2022 - nature.com
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

Reinventing radiobiology in the light of FLASH radiotherapy

CL Limoli, MC Vozenin - Annual Review of Cancer Biology, 2023 - annualreviews.org
Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …

Hypofractionated FLASH-RT as an effective treatment against glioblastoma that reduces neurocognitive side effects in mice

P Montay-Gruel, MM Acharya, P Gonçalves Jorge… - Clinical Cancer …, 2021 - AACR
Purpose: Recent data have shown that single-fraction irradiation delivered to the whole
brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit …

Radiobiology of the FLASH effect

AA Friedl, KM Prise, KT Butterworth… - Medical …, 2022 - Wiley Online Library
Radiation exposures at ultrahigh dose rates (UHDRs) at several orders of magnitude greater
than in current clinical radiotherapy (RT) have been shown to manifest differential …

Ultra‐high dose rate electron beams and the FLASH effect: from preclinical evidence to a new radiotherapy paradigm

E Schüler, M Acharya, P Montay‐Gruel… - Medical …, 2022 - Wiley Online Library
In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …

A potential revolution in cancer treatment: A topical review of FLASH radiotherapy

Y Gao, R Liu, CW Chang, S Charyyev… - Journal of Applied …, 2022 - Wiley Online Library
FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …

Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation

H Kacem, A Almeida, N Cherbuin… - International journal of …, 2022 - Taylor & Francis
A reemergence of research implementing radiation delivery at ultra-high dose rates
(UHDRs) has triggered intense interest in the radiation sciences and has opened a new field …

[HTML][HTML] Comparison of ultra-high versus conventional dose rate radiotherapy in a patient with cutaneous lymphoma

O Gaide, F Herrera, WJ Sozzi, PG Jorge, R Kinj… - Radiotherapy and …, 2022 - Elsevier
A patient with a cutaneous lymphoma was treated on the same day for 2 distinct tumors
using a 15 Gy single electron dose given in a dose rate of 0.08 Gy/second versus 166 …

Mechanisms of FLASH effect

B Lin, D Huang, F Gao, Y Yang, D Wu, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high
dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects …

Proton FLASH radiation therapy and immune infiltration: evaluation in an orthotopic glioma rat model

L Iturri, A Bertho, C Lamirault, M Juchaux… - International Journal of …, 2023 - Elsevier
Purpose FLASH radiation therapy (FLASH-RT) is a promising radiation technique that uses
ultrahigh doses of radiation to increase the therapeutic window of the treatment. FLASH-RT …