Although heart failure due to a wide variety of pathological stimuli including myocardial
infarction, pressure overload and volume overload is associated with cardiac hypertrophy …

The multifunctional Ca2+-and calmodulin-dependent protein kinase II (CaMKII) is now
recognized to play a central role in pathological events in the cardiovascular system. CaMKII …

Diabetic cardiomyopathy (DbCM), which consists of cardiac hypertrophy and failure in the
absence of traditional risk factors, is a major contributor to increased heart failure risk in type …

The animal models of myocardial injury induced by systemic β-adrenergic receptor agonist
administration represent an experimental approach of persisting interest. These models …

Background Heart failure (HF) is the most common potential cause of death, causing a huge
health and economic burden all over the world. So far, some impressive progress has been …

It is believed that cardiac remodeling due to geometric and structural changes is a major
mechanism for the progression of heart failure in different pathologies including …

Simple Summary Death from injury to the heart from a variety of causes remains a major
cause of mortality worldwide. The cardiomyocyte, the major contracting cell of the heart, is …

Phosphoinositide‐dependent protein kinase‐1 (Pdk1) as a serine/threonine protein kinase
plays a critical role in multiple signaling pathways. Analysis of the gene expression omnibus …

Mitochondria are essential for energy supply and cell signalling and may be triggers and
effectors of cell death. Mitochondrial respiration is tightly controlled by the matrix Ca2+ …

As cardiomyocytes have a limited capability for proliferation, renewal, and repair, the loss of
heart cells followed by replacement with fibrous tissue is considered to result in the …