Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

Despite its short history, diffraction-unlimited fluorescence microscopy techniques have
already made a substantial imprint in the biological sciences. In this review, we describe …

A ubiquitous observation in cell biology is that the diffusive motion of macromolecules and
organelles is anomalous, and a description simply based on the conventional diffusion …

Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …

Cholesterol-mediated lipid interactions are thought to have a functional role in many
membrane-associated processes such as signalling events,,,,. Although several …

Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …

The interaction of lipids and proteins plays an important role in plasma membrane
bioactivity, and much can be learned from their diffusion characteristics. Here we present the …

Lipid–protein interactions in cells are involved in various biological processes, including
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …

It is now recognized that lipids and proteins in cellular membranes are not homogenously
distributed. A high degree of membrane order is the biophysical hallmark of cholesterol …

Fluorescence correlation spectroscopy (FCS) is a single molecule sensitive tool for the
quantitative measurement of biomolecular dynamics and interactions. Improvements in …