The mystery of membrane organization: composition, regulation and roles of lipid rafts
Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …
subcompartments that differ in their biophysical properties and composition. A large number …
Stimulated emission depletion microscopy
H Blom, J Widengren - Chemical reviews, 2017 - ACS Publications
Despite its short history, diffraction-unlimited fluorescence microscopy techniques have
already made a substantial imprint in the biological sciences. In this review, we describe …
already made a substantial imprint in the biological sciences. In this review, we describe …
Anomalous transport in the crowded world of biological cells
F Höfling, T Franosch - Reports on Progress in Physics, 2013 - iopscience.iop.org
A ubiquitous observation in cell biology is that the diffusive motion of macromolecules and
organelles is anomalous, and a description simply based on the conventional diffusion …
organelles is anomalous, and a description simply based on the conventional diffusion …
Revitalizing membrane rafts: new tools and insights
K Simons, MJ Gerl - Nature reviews Molecular cell biology, 2010 - nature.com
Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
C Eggeling, C Ringemann, R Medda, G Schwarzmann… - Nature, 2009 - nature.com
Cholesterol-mediated lipid interactions are thought to have a functional role in many
membrane-associated processes such as signalling events,,,,. Although several …
membrane-associated processes such as signalling events,,,,. Although several …
Membrane lipid nanodomains
Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …
sizes and properties. The organization of membrane lipids into nanodomains might …
Scanning STED-FCS reveals spatiotemporal heterogeneity of lipid interaction in the plasma membrane of living cells
The interaction of lipids and proteins plays an important role in plasma membrane
bioactivity, and much can be learned from their diffusion characteristics. Here we present the …
bioactivity, and much can be learned from their diffusion characteristics. Here we present the …
Lipid–protein interactions in plasma membrane organization and function
Lipid–protein interactions in cells are involved in various biological processes, including
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …
Quantitative imaging of membrane lipid order in cells and organisms
It is now recognized that lipids and proteins in cellular membranes are not homogenously
distributed. A high degree of membrane order is the biophysical hallmark of cholesterol …
distributed. A high degree of membrane order is the biophysical hallmark of cholesterol …
Current capabilities and future perspectives of FCS: super-resolution microscopy, machine learning, and in vivo applications
J Sankaran, T Wohland - Communications Biology, 2023 - nature.com
Fluorescence correlation spectroscopy (FCS) is a single molecule sensitive tool for the
quantitative measurement of biomolecular dynamics and interactions. Improvements in …
quantitative measurement of biomolecular dynamics and interactions. Improvements in …