Human endogenous retroviruses are ancient acquired elements still shaping innate immune responses
N Grandi, E Tramontano - Frontiers in immunology, 2018 - frontiersin.org
About 8% of our genome is composed of sequences with viral origin, namely human
Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the …
Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the …
HERV envelope proteins: physiological role and pathogenic potential in cancer and autoimmunity
N Grandi, E Tramontano - Frontiers in microbiology, 2018 - frontiersin.org
Human endogenous retroviruses (HERVs) are relics of ancient infections accounting for
about the 8% of our genome. Despite their persistence in human DNA led to the …
about the 8% of our genome. Despite their persistence in human DNA led to the …
Role of viruses in the pathogenesis of multiple sclerosis
RE Tarlinton, E Martynova, AA Rizvanov… - Viruses, 2020 - mdpi.com
Multiple sclerosis (MS) is an immune inflammatory disease, where the underlying etiological
cause remains elusive. Multiple triggering factors have been suggested, including …
cause remains elusive. Multiple triggering factors have been suggested, including …
Oncogenic effects of HIV-1 proteins, mechanisms behind
M Isaguliants, E Bayurova, D Avdoshina… - Cancers, 2021 - mdpi.com
Simple Summary People living with human immunodeficiency virus type 1 (HIV-1)(PLWH)
are at increased risk of developing cancer despite successful antiretroviral therapy (ART) …
are at increased risk of developing cancer despite successful antiretroviral therapy (ART) …
HERVs and cancer—A comprehensive review of the relationship of human endogenous retroviruses and human cancers
E Stricker, EC Peckham-Gregory, ME Scheurer - Biomedicines, 2023 - mdpi.com
Genomic instability and genetic mutations can lead to exhibition of several cancer hallmarks
in affected cells such as sustained proliferative signaling, evasion of growth suppression …
in affected cells such as sustained proliferative signaling, evasion of growth suppression …
[HTML][HTML] Interplay between activation of endogenous retroviruses and inflammation as common pathogenic mechanism in neurological and psychiatric disorders
J Gruchot, F Herrero, U Weber-Stadlbauer… - Brain, Behavior, and …, 2023 - Elsevier
Human endogenous retroviruses (ERVs) are ancestorial retroviral elements that were
integrated into our genome through germline infections and insertions during evolution …
integrated into our genome through germline infections and insertions during evolution …
Human endogenous retrovirus (HERV) transcriptome is dynamically modulated during SARS-CoV-2 infection and allows discrimination of COVID-19 clinical stages
N Grandi, MC Erbì, S Scognamiglio… - Microbiology …, 2023 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 infection is known to trigger an important inflammatory response,
which has a major role in COVID-19 pathogenesis. In infectious and inflammatory contexts …
which has a major role in COVID-19 pathogenesis. In infectious and inflammatory contexts …
Transposable elements and their epigenetic regulation in mental disorders: current evidence in the field
B Misiak, L Ricceri, MM Sąsiadek - Frontiers in genetics, 2019 - frontiersin.org
Transposable elements (TEs) are highly repetitive DNA sequences in the human genome
that are the relics of previous retrotransposition events. Although the majority of TEs are …
that are the relics of previous retrotransposition events. Although the majority of TEs are …
Variation in proviral content among human genomes mediated by LTR recombination
Abstract Background Human endogenous retroviruses (HERVs) occupy a substantial
fraction of the genome and impact cellular function with both beneficial and deleterious …
fraction of the genome and impact cellular function with both beneficial and deleterious …
The epigenetic alterations of endogenous retroelements in aging
M Cardelli - Mechanisms of ageing and development, 2018 - Elsevier
Endogenous retroelements, transposons that mobilize through RNA intermediates, include
some of the most abundant repetitive sequences of the human genome, such as Alu and …
some of the most abundant repetitive sequences of the human genome, such as Alu and …