Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …

IgD emerged soon after IgM at the time of inception of the adaptive immune system. Despite
its evolutionary conservation from fish to humans, the specific functions of IgD have only …

Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like
nanoparticles to enhance B-cell activation. However, the effects of antigen copy number …

The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain
glycans (VDGs). Their abundant occurrence results from the selective introduction of N …

CD20 is a B cell-specific membrane protein and represents an attractive target for
therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies for B cell …

Glycosphingolipids (GSLs) exhibit a variety of functions in cellular differentiation and
interaction. Also, they are known to play a role as receptors in pathogen invasion. A less well …

Interferon-induced transmembrane protein 3 (IFITM3) has previously been identified as an
endosomal protein that blocks viral infection,–. Here we studied clinical cohorts of patients …

The actin cytoskeleton is essential for cell mechanics and has increasingly been implicated
in the regulation of cell signalling. In B cells, the actin cytoskeleton is extensively coupled to …

Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the
primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on …

Proximity assays are immunohistochemical tools that utilise two or more DNA-tagged
aptamers or antibodies binding in close proximity to the same protein or protein complex …