G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that are the
targets for many different classes of pharmacotherapy. The islets of Langerhans are central …

Obesity and the associated comorbidities are a growing health threat worldwide. Adipose
tissue dysfunction, impaired adipokine activity, and inflammation are central to metabolic …

Estrogens and their receptors play key roles in regulating body weight, energy expenditure,
and metabolic homeostasis. It is known that lack of estrogens promotes increased food …

Obesity and related inflammation are critical for the pathogenesis of insulin resistance, but
the underlying mechanisms are not fully understood. Formyl peptide receptor 2 (FPR2) plays …

Inflammation is essential to protect the host from exogenous and endogenous dangers that
ultimately lead to tissue injury. The consequent tissue repair is intimately associated with the …

Breast cancer is the most common type of cancer in women worldwide, with the luminal
subtype being the most widespread. Although characterized by better prognosis compared …

Obesity is a multifactorial disorder, and the gut microbiome has been suggested to
contribute to its onset. In order to better clarify the role of the microbiome in obesity, we …

Introduction: The timely resolution of inflammation is essential to restore tissue homeostasis
and to avoid chronic inflammatory diseases. Resolution of inflammation is an active process …

Hypertension is a predominant risk factor for cardiovascular diseases and a major health
care burden. Accumulating epidemiological and experimental evidence suggest that adult …

Abstract Background Annexin A1 (AnxA1) is a protein involved in inflammation resolution
that might be altered in obesity-associated type 2 diabetes mellitus (DM), which is a chronic …