The CD28 receptor is stimulated during the contact of T cells with antigen-presenting cells. A
counter-receptor for CD28 is the B7 molecule expressed on activated B cells, dendritic cells …

Antigen-specific T-ceil activation is initiated through the T-cell receptor. Recent evidence has
shown that a number of additional T-cell surface receptors serve to regulate the responses …

Functional interactions between T and B lymphocytes are necessary for optimal activation of
an immune response. Recently, the T lymphocyte receptor CD28 was shown to bind the B7 …

A successful immune response requires intercellular contact between T and B lymphocytes.
We recently showed that CD28, a T cell surface protein that regulates an activation pathway …

Studies using monoclonal antibodies (mAbs) have implicated the homodimeric glycoprotein
CD28 as an important regulator of human T-cell activation, in part by posttranscriptional …

Immunological mechanisms have been implicated in the pathogenesis of periodontal
disease for over 25 years. Studies throughout the 1970s established that advanced forms of …

Although multiple sclerosis (MS) patients and healthy individuals have similar frequencies of
myelin basic protein (MBP)-specific T cells, the activation state of these cells has not been …

Many abnormalities of humoral and cellular immunity associated with the acquired
immunodeficiency syndrome can be explained by the preferential infection of the T4 …

In previous studies (17-21), monoclonal antibody (mAb) 9.3 has been shown to react with a
major population of human T cells, which include T4+ helper/inducer T cells and T8+ …

The two-signal model of T-cell activation, proposed approximately four decades ago, has
undergone various refinements while maintaining its principal doctrine. Since the discovery …