Molecular mechanisms of chemo‐and radiotherapy resistance and the potential implications for cancer treatment

YP Liu, CC Zheng, YN Huang, ML He, WW Xu… - MedComm, 2021 - Wiley Online Library
Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …

5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes

S Blondy, V David, M Verdier, M Mathonnet… - Cancer …, 2020 - Wiley Online Library
Colorectal cancer (CRC) is a public health problem. It is the third most common cancer in the
world, with nearly 1.8 million new cases diagnosed in 2018. The only curative treatment is …

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

YH Cho, EJ Ro, JS Yoon, T Mizutani, DW Kang… - Nature …, 2020 - nature.com
Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-
FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective …

The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota

KD LaCourse, M Zepeda-Rivera, AG Kempchinsky… - Cell Reports, 2022 - cell.com
Fusobacterium nucleatum (Fn) is a dominant bacterial species in colorectal cancer (CRC)
tissue that is associated with cancer progression and poorer patient prognosis. Following a …

5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy

AA Valencia-Lazcano, D Hassan, M Pourmadadi… - European Journal of …, 2023 - Elsevier
Fluorouracil (5-FU) is amongst the most commonly used antimetabolite chemotherapeutic
agents in recent decades. However, its low bioavailability, short half-life, rapid metabolism …

The current treatment paradigm for pancreatic ductal adenocarcinoma and barriers to therapeutic efficacy

DR Principe, PW Underwood, M Korc… - Frontiers in …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a median survival
time of 10-12 months. Clinically, these poor outcomes are attributed to several factors …

[HTML][HTML] Battling chemoresistance in cancer: root causes and strategies to uproot them

A Ramos, S Sadeghi, H Tabatabaeian - International journal of molecular …, 2021 - mdpi.com
With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …

Drug resistance in cancer: an overview

G Housman, S Byler, S Heerboth, K Lapinska… - Cancers, 2014 - mdpi.com
Cancers have the ability to develop resistance to traditional therapies, and the increasing
prevalence of these drug resistant cancers necessitates further research and treatment …

[HTML][HTML] The role of miRNAs in colorectal cancer progression and chemoradiotherapy

N Zhang, X Hu, Y Du, J Du - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Colorectal cancer (CRC) is known as the third most common cancer as well as the fourth
most deadly cancer worldwide. CRC accounts for approximately 10% of all new cancer …

Metal-organic framework nanoshell structures: preparation and biomedical applications

J Tang, C Huang, Y Liu, T Wang, M Yu, H Hao… - Coordination Chemistry …, 2023 - Elsevier
The integration of metal-organic frameworks (MOFs) and nanoshells to construct MOF
nanoshell structures offers promising therapeutic platforms for biomedical applications …