Molecular mechanisms of chemo‐and radiotherapy resistance and the potential implications for cancer treatment
YP Liu, CC Zheng, YN Huang, ML He, WW Xu… - MedComm, 2021 - Wiley Online Library
Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …
cancer, but the survival rate is very low due to the rapid progression of the disease and …
5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes
S Blondy, V David, M Verdier, M Mathonnet… - Cancer …, 2020 - Wiley Online Library
Colorectal cancer (CRC) is a public health problem. It is the third most common cancer in the
world, with nearly 1.8 million new cases diagnosed in 2018. The only curative treatment is …
world, with nearly 1.8 million new cases diagnosed in 2018. The only curative treatment is …
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
YH Cho, EJ Ro, JS Yoon, T Mizutani, DW Kang… - Nature …, 2020 - nature.com
Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-
FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective …
FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective …
The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota
Fusobacterium nucleatum (Fn) is a dominant bacterial species in colorectal cancer (CRC)
tissue that is associated with cancer progression and poorer patient prognosis. Following a …
tissue that is associated with cancer progression and poorer patient prognosis. Following a …
5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy
Fluorouracil (5-FU) is amongst the most commonly used antimetabolite chemotherapeutic
agents in recent decades. However, its low bioavailability, short half-life, rapid metabolism …
agents in recent decades. However, its low bioavailability, short half-life, rapid metabolism …
The current treatment paradigm for pancreatic ductal adenocarcinoma and barriers to therapeutic efficacy
DR Principe, PW Underwood, M Korc… - Frontiers in …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a median survival
time of 10-12 months. Clinically, these poor outcomes are attributed to several factors …
time of 10-12 months. Clinically, these poor outcomes are attributed to several factors …
[HTML][HTML] Battling chemoresistance in cancer: root causes and strategies to uproot them
With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …
major key parameters that control cancer treatment management, such as diagnosis …
Drug resistance in cancer: an overview
G Housman, S Byler, S Heerboth, K Lapinska… - Cancers, 2014 - mdpi.com
Cancers have the ability to develop resistance to traditional therapies, and the increasing
prevalence of these drug resistant cancers necessitates further research and treatment …
prevalence of these drug resistant cancers necessitates further research and treatment …
[HTML][HTML] The role of miRNAs in colorectal cancer progression and chemoradiotherapy
Colorectal cancer (CRC) is known as the third most common cancer as well as the fourth
most deadly cancer worldwide. CRC accounts for approximately 10% of all new cancer …
most deadly cancer worldwide. CRC accounts for approximately 10% of all new cancer …
Metal-organic framework nanoshell structures: preparation and biomedical applications
J Tang, C Huang, Y Liu, T Wang, M Yu, H Hao… - Coordination Chemistry …, 2023 - Elsevier
The integration of metal-organic frameworks (MOFs) and nanoshells to construct MOF
nanoshell structures offers promising therapeutic platforms for biomedical applications …
nanoshell structures offers promising therapeutic platforms for biomedical applications …