Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with
synovial tissue proliferation, pannus formation, cartilage destruction, and systemic …

Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …

Background In previous human skin single-cell data, inflammatory cells constituted only a
small fraction of the overall cell population, such that functional subsets were difficult to …

As a major arm of the cellular immune response, CD4+ T cells are important in the control
and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral …

Multiple sclerosis (MS) is a frequent autoimmune demyelinating disease of the central
nervous system (CNS). There are three clinical forms described: relapsing-remitting multiple …

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by loss of immune
tolerance and chronic inflammation. It is pathogenesis complex and includes interaction …

The discovery of IL-10 more than 30 years ago marked the beginning of our understanding
of how cytokines regulate immune responses, based on cross-regulation between Th1 and …

Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults just in the
US. Previously, psoriasis immunopathogenesis has been viewed as the imbalance between …