Recent years have seen the rapid proliferation of clinical prediction models aiming to
support risk stratification and individualized care within psychiatry. Despite growing interest …

Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major
depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can …

BackgroundIrremediability is a key requirement for euthanasia and assisted suicide for
psychiatric disorders (psychiatric EAS). Countries like the Netherlands and Belgium ask …

Background Predicting rTMS nonresponse could be helpful in sparing patients from futile
treatment, and in improving use of limited rTMS resources. While several predictive …

Background Major depressive disorder (MDD) is a leading cause of disability worldwide and
most people do not achieve symptom remission. Treatment‐resistant depression (TRD) is …

Major problems of current antidepressant pharmacotherapy are insufficient response rates
and difficulties in response prediction. We recently provided preliminary evidence in a small …

Background Symptoms of major depressive disorder (MDD) are reported to change early in
treatment with repetitive transcranial magnetic stimulation (rTMS). We evaluated early …

Background Prior studies have demonstrated that early treatment response with transcranial
magnetic stimulation (TMS) can predict overall response, yet none have directly compared …

Background Determining when to recommend a change in treatment regimen due to
insufficient improvement is a common challenge in therapeutics. Methods In a sample of …

Background Sub-anesthetic ketamine doses rapidly reduce depressive symptoms, although
additional investigations of the underlying neural mechanisms and the prediction of …