Although acute exposure of the heart to angiotensin (Ang II) produces physiological cardiac
hypertrophy and chronic exposure results in pathological hypertrophy, the signal …

The contribution of natural products (NPs) to cardiovascular medicine has been extensively
documented, and many have been used for centuries. Cardiovascular disease (CVD) is the …

The therapeutic potential of venom-derived drugs is evident today. Currently, several
significant drugs are FDA approved for human use that descend directly from animal venom …

Angiotensin-converting enzyme (ACE) inhibitors, which prevent the conversion of
angiotensin I to angiotensin II, are well-known for the treatments of cardiovascular diseases …

Purpose: Enalapril has an established safety and efficacy in adults and is used in
hypertension, heart failure, and renal failure. In pediatric patients, enalapril is labeled for …

GTP cyclohydrolase II converts GTP to 2, 5-diamino-6-β-ribosyl-4 (3H)-pyrimidinone 5′-
phosphate, formate and pyrophosphate, the first step in riboflavin biosynthesis. The …

Background Paclitaxel (PCX) is the first‐line choice for the treatment of several types of
cancer, including breast, ovarian, and lung cancers. However, patients who receive even a …

Metastatic melanoma originates from melanocytes of the skin. Melanoma metastasis results
in poor treatment prognosis for patients and is associated with epigenetic and transcriptional …

Alanine (3a) was reacted with a preformed 4 M solution of phosgene in THF; this removed
phosgene as a rate-limiting reagent, and any large-scale thermal contribution due to the …

We are all familiar with the enzymic hydrolysis of peptide bonds, at least in the context of
gastrointestinal digestion of ingested proteins. Our view of the proteolytic enzymes and their …