New frontiers in obesity treatment: GLP-1 and nascent nutrient-stimulated hormone-based therapeutics

AM Jastreboff, RF Kushner - Annual review of medicine, 2023 - annualreviews.org
Nearly half of Americans are projected to have obesity by 2030, underscoring the pressing
need for effective treatments. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) …

Small bioactive peptides for biomaterials design and therapeutics

IW Hamley - Chemical reviews, 2017 - ACS Publications
This review is aimed to provide a concise yet extensive survey of key short bioactive peptide
sequences for a range of applications ranging from biomaterials development to peptides …

Health effects of resistant starch

S Lockyer, AP Nugent - Nutrition bulletin, 2017 - Wiley Online Library
The merits of a fibre‐rich diet are well documented. Resistant starch (RS) is a form of starch
that resists digestion in the small intestine and, as such, is classified as a type of dietary …

The pathogenesis of obesity

SM Oussaada, KA Van Galen, MI Cooiman… - Metabolism, 2019 - Elsevier
Body fat mass increases when energy intake exceeds energy expenditure. In the long term,
a positive energy balance will result in obesity. The worldwide prevalence of obesity has …

Glucose transporters in the small intestine in health and disease

H Koepsell - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
Absorption of monosaccharides is mainly mediated by Na+-d-glucose cotransporter SGLT1
and the facititative transporters GLUT2 and GLUT5. SGLT1 and GLUT2 are relevant for …

[HTML][HTML] Secretin-activated brown fat mediates prandial thermogenesis to induce satiation

Y Li, K Schnabl, SM Gabler, M Willershäuser, J Reber… - Cell, 2018 - cell.com
The molecular mediator and functional significance of meal-associated brown fat (BAT)
thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non …

Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence?

MEJ Lean, D Malkova - International journal of obesity, 2016 - nature.com
The aim of this article is to review the research into the main peripheral appetite signals
altered in human obesity, together with their modifications after body weight loss with diet …

Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance

HJ Grill, MR Hayes - Cell metabolism, 2012 - cell.com
This Review highlights the processing and integration performed by hindbrain nuclei,
focusing on the inputs received by nucleus tractus solitarius (NTS) neurons. These inputs …

[HTML][HTML] Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding

MO Dietrich, MR Zimmer, J Bober, TL Horvath - Cell, 2015 - cell.com
The nervous system evolved to coordinate flexible goal-directed behaviors by integrating
interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial …

Dietary fiber and satiety: the effects of oats on satiety

CJ Rebello, CE O'Neil, FL Greenway - Nutrition reviews, 2016 - academic.oup.com
This review examines the effect of β-glucan, the viscous soluble fiber in oats, on satiety. A
literature search for studies that examined delivery of the fiber in whole foods or as an …