Despite the existence of extensive clinical research and novel therapeutic treatments,
cancer remains undefeated and the significant cause of death worldwide. Cancer is a …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-
menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present …

Bladder cancer (BCa) is a common malignancy with uncertain molecular mechanism. 7-
dehydrocholesterol reductase (DHCR7), the enzyme of mammalian sterol biosynthesis …

Prostate cancer (PCa) continues to rank as the second leading cause of cancer-related
mortality in western countries, despite the golden treatment using androgen deprivation …

Prostate cancer (PCa) is the second most frequent type of cancer in men and assessing
circulating tumor cells (CTCs) by liquid biopsy is a promising tool to help in cancer early …

PTEN has been implicated in the repair of DNA double-strand breaks (DSBs), particularly
through homologous recombination (HR). However, other data fail to demonstrate a direct …

Colorectal cancer (CRC) is the third most common cancer and the 4th leading cause of
cancer-related deaths, although with a dismal prognosis. The SIAH E3 Ubiquitin Protein …

Prostate cancer (PCa) is today the second most common cancer in the world, with almost
400,000 deaths annually. Multiple factors are involved in the etiology of PCa, such as older …

Simple Summary Prostate cancer remains the most frequent cause of cancer morbidity, the
second most frequent cause of cancer mortality in men in the developed world and is an …