Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500)
ATR is a key kinase in the DNA-damage response (DDR) that is synthetic lethal with several
other DDR proteins, making it an attractive target for the treatment of genetically selected …
other DDR proteins, making it an attractive target for the treatment of genetically selected …
DNA damage response defects in hematologic malignancies: mechanistic insights and therapeutic strategies
The DNA damage response (DDR) encompasses the detection and repair of DNA lesions
and is fundamental to the maintenance of genome integrity. Germ line DDR alterations …
and is fundamental to the maintenance of genome integrity. Germ line DDR alterations …
Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions
In the modern era of Chronic Lymphocytic Leukemia (CLL) targeted therapy, the loss of p53
function due to genetic abnormalities remains a significant challenge. This is because even …
function due to genetic abnormalities remains a significant challenge. This is because even …