Human cancer cell lines are commonly used in basic cancer research to understand the
behavior of primary tumors. Aberrations in the DNA methylation patterns are nowadays …

Exposure to arsenic in contaminated drinking water is an emerging public health problem
that impacts more than 200 million people worldwide. Accumulating lines of evidence from …

Many genetic and environmental factors contribute to development of cancer, but DNA
methylation may provide a link between these influences. Genome stability and normal gene …

Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to
cancer progression and metastasis. It is now well understood that both losses and gains of …

In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …

To identify novel methylated gene promoters, we compared differential RNA expression
profiles of colorectal cancer (CRC) cell lines with or without treatment of 5-aza-2 …

Uterine leiomyomas, also known as uterine fibroids, are the most common pelvic tumors,
occurring in nearly 70% of all reproductive-aged women and are the leading indication for …

Breast cancer is a complex disease caused by the progressive accumulation of multiple
gene mutations combined with epigenetic dysregulation of critical genes and protein …

Introduction BRCA1 or BRCA2 germline mutations increase the risk of developing breast
cancer. Tumour cells from germline mutation carriers have frequently lost the wild-type …

Increased methylation of CpG islands and silencing of affected target genes is frequently
found in human cancer; however, in vivo the question of causality has only been addressed …