Microenvironment-responsive drug delivery systems (DDSs) can achieve targeted drug
delivery, reduce drug side effects and improve drug efficacies. Among them, pH-responsive …

The past two decades have witnessed a rapid progress in the development of surface
charge‐reversible nanoparticles (NPs) for drug delivery and diagnosis. These NPs are able …

Protein and peptide drugs are predominantly administered by injection to achieve high
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …

Oral drug delivery is considered the most preferred mode of treatment because of its high
patient compliance and minimal invasiveness. However, the oral delivery of protein drug has …

Ligand-modified nanocarriers (LMNCs) specific to their targets have attracted increasing
interest for enhanced oral drug delivery in recent decades. Although the design of LMNCs …

A brain-targeting nanodelivery system has been a hot topic and has undergone rapid
progression. However, due to various obstacles such as the intestinal epithelial barrier (IEB) …

Gene-photothermal synergistic therapy shows great potential for breast cancer treatment.
Polydopamine (PDA) is a widely used photothermal therapeutic agent and delivery vector …

Telomerase is constitutively overexpressed in the majority of human cancers and
telomerase inhibition provides a promising broad-spectrum anticancer therapeutic strategy …

Chitosan (Cs) was subjected to ball milling and subsequently functionalized with Dinitro
salicylic acid (Cs-DNS) to enhance the efficacy of oral insulin delivery. The hydrodynamic …

Oral insulin therapies targeting the liver and further simulating close‐looped secretion face
significant challenges due to multiple trans‐epithelial barriers. Herein, ursodeoxycholic acid …