This review examines the shared immune-inflammatory, oxidative and nitrosative stress
(IO&NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder …

Complement system is one of the most important defense mechanisms of the innate immune
system. In addition to their roles in immune regulation, complement proteins are also …

Objective Anhedonia is a core symptom of major depressive disorder (MDD) and often
associated with poor prognosis. The main objective of the present study was to explore the …

Depression is one of the most frequent psychiatric symptoms observed in people during the
development of Alzheimer's disease (AD). We hypothesized that genetic factors conferring …

The complement cascade is a major component of the immune defence against infection,
and there is increasing evidence for a role of dysregulated complement in major psychiatric …

Background Dysregulated complement system is linked to pathophysiology of major
depressive disorder (MDD). Childhood trauma has been associated with an increased …

Objective Exacerbated inflammatory pathway has emerged as a predominant etiological
construct of major depressive disorder (MDD). Innate immune molecules like complement …

Major depressive disorder (MDD) has a high prevalence worldwide. Although the economic
burden of depression increases annually, the proportion of patients with MDD receiving …

Background Autism spectrum disorder (ASD) is often accompanied by intellectual disability
(ID). Despite extensive studies, however, the genetic basis for this comorbidity is still not …

Our previous work implied that interleukin 6 (IL6) may be a biological marker for major
depressive disorder (MDD). In this study, we performed a comprehensive genetic study to …