Multiple pathological mechanisms are involved in the development of chemotherapy-
induced peripheral neurotoxicity (CIPN). Recent work has provided insights into the …

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease
that leads to the massive loss of motor neurons in cerebrum, brain stem and spinal cord. It …

Calcium (Ca2+) is a versatile secondary messenger involved in the regulation of a plethora
of different signaling pathways for cell maintenance. Specifically, intracellular Ca2+ …

Methamphetamine (Meth) abuse can cause serious mental disorders, including anxiety and
depression. The gut microbiota is a crucial contributor to maintaining host mental health …

Introduction Depression is a common mental disorder that affects approximately 350 million
people worldwide. Much remains unknown about the molecular mechanisms underlying this …

Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or
heme and also several unrelated xenobiotics/chemicals. They reside in the plasma …

Abstract Background Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic
reticulum (ER)-mitochondria signaling plays a key role in the neuronal cytopathology of …

Neurodegenerative diseases (NDDs) are characterized by progressive deterioration of the
structure and function of cells and their networks in the nervous system. There are currently …

The prevalence of diabetes-associated cognitive dysfunction (DACD) has increased to
13.5%. Dementia, as the most severe DACD, is the second leading cause of death in …

Abstract Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the
endoplasmic reticulum. Since S1R agonists exhibit potent antidepressant-like activity, S1R …